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Researchers collected several small muscle samples from the thigh to measure pyruvate dehydrogenase activity ( PDH , an enzyme complex that helps muscles convert carbohydrate fuel into energy inside mitochondria), along with changes in gene expression and protein levels related to oxidative phosphorylation ( OXPHOS , the main process mitochondria use to produce energy)

Manisalidis I, Stavropoulou E, Stavropoulos A, Bezirtzoglou E

46 Similarly, the mRNA levels of E2G2 and UBC2 are elevated in human heart failure, implicating these enzymes in the progression of cardiac dysfunction