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In support of the idea that cross-protective immunity exists, recent HCoV infections were found to be associated with less severe COVID-19 upon infection with ancestral SARS-CoV-2 [103], and infection with SARS-CoV-2 of any variant was also associated with a reduced incidence of subsequent HCoV infection

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[DOI] [PubMed] [Google Scholar] [59].Loguercio C, Clot P, Albano E, Argenzio F, Grella A, De Girolamo V, et al