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Several high-profile athletes have faced suspensions after testing positive for these recovery agents, making their use a massive risk in competitive sports

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Metformin may result in suboptimal oral vitamin B12 absorption by competitively blocking the calcium-dependent binding of the intrinsic factor-vitamin B12 complex to its receptor

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These findings underscore the potential of targeting circSCUBE3/CREB/GPX4 as a novel therapeutic strategy for LUAD ( Overall, circRNAs are emerging as vital regulators of ferroptosis in lung cancer by functioning as miRNA sponges (e.g., circDTL/miR-1287-5p/GPX4 axis) and influencing redox homeostasis (Table 4) (Figure 3) (Wu et al., 2024)