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It may be possible that Parasympathetic Excess causes overactive and persistent immune responses that may lead to autoimmunity

This latter observation is characteristic of this TBI model where the impactor probe hits a metallic disk affixed to the closed skull, causing a diffusion of the injury throughout the cortex

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Clin Biochem 42(6):462466 Benussi A, Alberici A, Buratti E, Ghidoni R, Gardoni F, Di Luca M, Padovani A, Borroni B (2019) Toward a glutamate hypothesis of frontotemporal dementia