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(PubMed) Sakaguchi Y, Hamano T, Nakano C, et al

To this end, both the endogenous antioxidant catalase and the glutathione system, which function downstream of SOD to convert H 2 O 2 to H 2 O and O 2 , have been extensively investigated

The interplay between pharmacokinetic genesnotably CYP2C19 and CYP2D6 and pharmacodynamic genes such as SLC6A4 (the serotonin transporter) and HTR2A (the serotonin 2A receptor) provides a comprehensive framework to explain the wide heterogeneity observed in patient responses to selective serotonin reuptake inhibitors (SSRIs)