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Advancements in particle engineering for inhalation delivery of small molecules and biotherapeutics

Toxicokinetics (the pharmacokinetics of a drug under circumstances that produce toxicity or excessive exposure) may differ significantly after poisoning, and these differences may profoundly alter treatment decisions and prognosis

Although ERT offers mutation-independent metabolic control, injectable agents such as pegtibatinase face lifetime adherence and immunogenicity hurdles, and oral agents such as SYNT-202 still require durable efficacy and safety data

Effects On Blood Pressure Initiation of hydroxocobalamin infusion as part of the therapeutic interventions generally resulted in increases in blood pressure and variable changes in heart rate (often normalization)

These findings not only enhance our understanding of the pathological mechanisms underlying CNDs but also provide important theoretical support for the development of new intervention strategies