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72 Early onset of jaundice is a commonly used indication for workup for possible PFIC2 after exclusion of common causes of hyperbilirubinemia in infancy

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These resistances reduce the long-term effectiveness of treatments, underscoring the need for novel therapies or combination strategies to overcome them

Each individual KLOW component has published preclinical research, but the specific quad-blend combination has not been systematically evaluated in published clinical studies