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The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation

According to coauthor Dr

This interplay between inflammation and oxidative stress is a critical feature of sepsis pathophysiology 9 , ultimately causing apoptosis and, consequently, organ failure

Within this section on therapeutics, both clinical and experimental approaches are stratified by CNS-localized or systemic mechanism-of-action

An essential role of interleukin-1beta in mediating NF-kappa B activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia