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Targeting ferroptosis thus offers a promising avenue for precision oncology in renal cancer, warranting further development of selective inducers and biomarker-guided therapeutic regimens

Glutathione protective mechanisms Recently, studies have further demonstrated the negative effects of oxidative stress and impaired redox signaling in the onset of OA, aggravating significant oxidative damage of cellular structures and vital molecules in cartilage as well as other tissues

In SLE, serum SR-G1 and platelet LGALS3BP levels also correlate with LN severity (229, 314), pointing to systemic involvement beyond the CNS

Indeed, because more than 100 proteins have been reported as TG2 substrates and because TG2 has broad substrate specificity, the GST tag could be crosslinked with a number of cellular proteins 21

Vesterdal LK, Jantzen K, Sheykhzade M, Roursgaard M, Folkmann JK, Loft S, et al