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However, Nrf2 acts as a double-edged sword having both antioncogenic and prooncogenic activities

The reaction between RT and GSH is based on a Michael addition reaction that is inherently reversible, has an appropriate dissociation equilibrium constant K d in the mM range and rapid reaction kinetics, and provides ratiometric readouts, thus allowing GSH quantification independent of the probe concentration

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Studies have shown that the coupling of ACSS2 and KAT7 can regulate H3K9bhb modification to promote the transcription of tumour-related genes (such as SAMD9 and FRMD3), thereby affecting the proliferation and invasion of tumour cells (75)

Wenjun Ouyang