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Enhanced glutamine anaplerosis underlies extracellular glutamine dependency in TNBC cells To elucidate the mechanism underlying glutamine dependency in TNBC cells, we first assessed oxygen consumption rate (OCR) in TNBC and luminal BC cells, given that glutamine serves as a critical carbon source for replenishing the tricarboxylic acid (TCA) cycle

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Test Principle: Glutathione peroxidase 4 (GPX4) is a kind of glutathione peroxidase containing selenocysteine, which can reduce phospholipid hydroperoxide to phosphatidyl alcohol, thus protecting the cell membrane from oxidative damage

Unlike the incretin-based best peptides for weight loss, MOTS-C is an endogenous molecule whose circulating levels decline with age, suggesting a role in metabolic aging