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In human CECs (HCECs) exposed to phenylarsine oxide (PAO), a highly toxic trivalent arsenical, significant oxidative stress was reported by Kandhari et al., accompanied by ferroptotic cell death (115)

[PubMed: 24425668] (Retrospective analysis of cases of acute liver failure admitted to 6 liver transplant centers in Argentina between 2005 and 2011 identified 154 cases, 16 [10%] were attributed to drugs or toxins, but none to acetaminophen overdose)

doi: 10.3390/plants10050944 25 JaakolaL

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