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Liver tissue health has mildly improved in the groups receiving GSH treatment, and VCO treatment

90 Carnitine The non-essential amino acid carnitine plays a vital role in mitochondrial function and cellular metabolism

In one retrospective study the administration of rFeIFN at 1 MU/kg SC q24 h for 3 days did not lead to increased survival rates (Porporato et al., 2018), although mortality in that study was very high at 80%

A significantly decreased MDA level following riboflavin therapy has also been reported in experimental models of several other diseases such as acute lung injury (Reference Al-Harbi, Imam and Nadeem22) , hepatotoxicity (Reference Al-Harbi, Imam and Nadeem25,Reference Bashandy, Ebaid and Moussa26) , diabetes (Reference Alam, Iqbal and Naseem31) and cisplatin- (a chemotherapy medication) induced toxicities (Reference Naseem, Hassan and Alhazza28,Reference Salman and Naseem29)

In addition, their screened genes such as SCP2, MAPK, and PRKAA1 were proved to implicated in multiple aspects of cellular ferroptosis