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Approaches evaluated to modulate or support glutathione status include: Precursor Support: Compounds such as N-acetyl cysteine (NAC), curcumin, and certain sulfur-containing or phytochemical-rich foods (e.g., broccoli, spinach) may support endogenous synthesis by providing precursors or upregulating synthesis pathways

A decrease in SCFA-producing bacteria, especially butyrate producers like Faecalibacterium and Roseburia from the Firmicutes phylum , along with certain Bacteroides species, has been observed in ME/CFS patients [10, 25, 28]

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