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It appears to upregulate vascular endothelial growth factor (VEGF), a key signalling protein that triggers the growth of new capillaries into damaged tissue

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Most men inject 1-2cc (200-400mg) per dose

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6 , e198 (2008)

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This is sometimes called methotrexate fog, and can occur a day after receiving a dose of methotrexate (which is taken in pill form or injected once a week)

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The dimer interface is formed by the interaction between loop 2 of one monomer and loop 1 of the other, stabilized by hydrogen bonds and salt bridges, resulting in a more open and flexible active site pocket compared to other GCTs

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