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Also, a study carried out in 2019 by Kim et al

PMID 12581423

The time to reach steady state for orforglipron is approximately 14-21 days of once-daily dosing, consistent with its terminal half-life

Embryo quality on Day 3 was assessed according to standards established by the Istanbul consensus workshop, evaluating the degree of fragmentation, uniformity of blastomeres, and the presence of multinucleation