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Non-oral routes, such as intravenous injection, can bypass some of these issues

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Figure 18: [k3= association constant of EB and A into EAB , k-3=dissociation constant of EAB into EB and A, [EAB]=enzyme-substrate-A-B-complex concentration, [A]=concentration of substrate A, [EB]=enzyme-substrate B-complex concentration] Equation 4: Figure 19: Fourth part of the rapid equilibrium random sequential bi-bi mechanism