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Pfeifer H, Conrad M, Roethlein D, Kyriakopoulos A, Brielmeier M, Bornkamm GW et al

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Traditional therapies primarily rely on RAAS blockers, such as ACE inhibitors or ARBs, which can slow albuminuria progression but offer limited efficacy in late-stage DN and fail to reverse renal fibrosis (Samsu, 2021)