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ChenSJiang PP YuDLiaoGCWuSLFangAPet al

These proteins contain an N-terminus bHLH domain that binds to DNA at specific sites (E-boxes) and a C-terminus Twist box domain that controls whether genes are turned on or off

Available diagnostic criteria Despite its high prevalence, there are still no universally accepted clinical criteria to characterise ME/CFS, making early and accurate diagnosis difficult (52)