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Studies have shown that EGCG negatively regulates the expression of genes associated with Atrogin-1, a key protein in the ubiquitin-mediated protein degradation process, while also acting on other proteins of the F-BOX family, contributing to the prevention or mitigation of the progression of cachexia both in vitro and in vivo (Wang et al., 2011)

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Clinical studies have shown that berberine (BBR), a natural plant alkaloid and major pharmacological component in the Chinese herb Coptis chinensis Franch, significantly increases secondary or total bile acid content and activates intestinal FXR signalling by accumulating taurocholic acid (TCA) (Tian et al., 2019)