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May also play a role in the immune system and may inhibit cancer growth and stimulate cell differentiation

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In one case, increased T2 signal intensity was observed in the cervical segment of the spine [67]

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On the other hand, double Ghr ko/ Igf1 ko resulted in further postnatal growth retardation relative to Igf1 ko mice completely obstructing further weight gain after postnatal day 15 and supporting previous studies suggesting that progenitor cells in the growth plate require direct GH actions (24)