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Magnesium supplementation has been shown to be effective in reducing the frequency and severity of heart palpitations. A statement from a healthcare professional Potential Side Effects of High Doses High doses of magnesium can cause side effects like diarrhea and nausea

The dl-PHPB is a novel drug candidate for ischemic stroke that has been shown to prevent neuropathological changes, inhibit oxidative damage, and reduce inflammatory reactions (42)

Some people claim that supplemental GABA has a calming effect on them, possibly due to changes via the gut-brain axis.[ref] You may want to try supplemental GABA if you have gut issues