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Reduced BDNF availability may in turn limit TrkB phosphorylation and attenuate downstream PI3K/Akt and MAPK/ERK signaling (Numakawa and Kajihara, 2023)

Nanomaterials 15 (2), 126

The commonly used chemotherapy TMZ not only blocked autophagy induced by BT317 in vitro but also showed enhanced synergy with BT317

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Given the incidence of paronychia with FGFR inhibitors, we typically include education around paronychia management and especially vinegar soaks as part of initial chemotherapy education sessions