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PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

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Specifically, they demonstrate profound efficacy in inhibiting macrophage M1 polarization, blocking neutrophil extracellular trap (NET) formation, ameliorating mitochondrial bioenergetic crises, and alleviating sepsis-associated encephalopathy (SAE)

Whether it was the aggressiveness of the rd10 model, or the loss of potency of the stored solutions, or a combination that led to only partial protection, future work in animal models is warranted with more translationally viable compositions