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Increasing GSH through synthesis would also seem to be useful therapeutically but as oxidants and most electrophiles would not seem appropriate, natural compounds such as curcumin, a principal ingredient of curry powder (Dickinson et al., 2003), and sulforaphane, a potent Phase II gene-inducing compound in broccoli, (Brooks et al., 2001) have been proposed but none of these natural has actually become a major therapeutic agent

Methods for detecting insulin resistance Hyperinsulinemic euglycemic glucose clamp technique This technique is a gold standard and reference method for quantifying insulin sensitivity because it directly measures effects of insulin in promoting glucose utilization under steady-state conditions in vivo

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These studies found no evidence of toxicity, organ damage, or concerning changes with chronic administration

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