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The reliability of the available data is moderate but uneven across compounds: ALA is supported by extensive experimental and clinical studies, UA by strong mechanistic and animal evidence with emerging human trials, and EGT mainly by cellular research and epidemiological observations

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NTBI, a hallmark of iron overload, increases vascular endothelial permeability and adhesion by promoting oxidation and mediating the release of vascular endothelial growth factor (VEGF)