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The relationship between innate and adaptive immunity underscores their value: innate triggers, such as DAMPs from stressed melanocytes, may initiate adaptive responses via antigen presentation, creating a self-amplifying loop

The activation of the NLRP3 inflammasome further mediates intestinal inflammation (Liu et al., 2023)

Of note, CRP levels are directly related to those of IL-6 (171), and IL-6 together with TNF- concurs to reduce the sensitivity to insulin action (172, 173)