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The data herein suggests that GPx1 deficiency could underlie the increased susceptibility of macrophages from patients with active CD for increased H 2 O 2 -cytotixicity

10.1007/s00204-016-1692-0 Arch

Among tyrosine kinase inhibitors, imatinib (a PDGFR inhibitor) and erlotinib (an EGFR inhibitor) induce ROS-dependent apoptosis in melanoma and non-small-cell lung cancer cells, respectively, through disruption of mitochondrial membrane potential upon the stimulation of JNK and p38 phosphorylation 88,89 , while vemurafenib (a BRAF inhibitor) increases the production of superoxide anions with the commensurate depolarization of the mitochondrial membranes in melanoma cells 90

Park SY, Love TM, Perelson AS, Mack WJ, Lee HY Retrovirology

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