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The AUCCSF/AUCplasma ratio after nasal delivery does not differ from the ratio after intravenous infusion, indicating that hydroxocobalamin enters the CSF via the blood circulation across the blood-brain barrier (BBB)

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Furthermore, this pathway may be beneficial for the rapid regulation of cellular iron homeostasis since the activation of Nrf2 and subsequently HO-1 increases Fe 2+ or because the activation of NCOA4, which induces ferritinophagy to further release Fe 2+ from FTH, seems to be a relatively slow process