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OSBORNE, A.D., PITTS, J.N., & DARLEY, E.F

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Methods: The data of TCGA, CPTAC and GEO databases were adopted for the survival analysis

Upon encountering DSBs, NHEJ is initiated by the binding of the Ku70/80 heterodimer to the free DNA ends, facilitating the assembly of essential NHEJ components such as DNA-dependent protein kinase catalytic subunit (DNA-PKcs), X-ray repair cross-complementing protein 4 (XRCC4), and DNA ligase IV (LIG4)