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Discussion The vulnerability of dopaminergic neurons to minor perturbations in redox equilibrium is enhanced by the oxidative by-products of dopamine metabolism, resulting in their selective loss in Parkinsons disease

Among these, PARP-1 is the predominant enzyme, characterized by its abundance and strong enzymatic activity

doi:10.1186/1471-2105-7-386

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Additionally, FGF-21 reduces Keap1-Nrf2 binding, thereby inhibiting oxidative stress and preserving BBB integrity [243]