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Only 11.2% of participants stopped the trial due to side effects, and the discontinuation rate dropped significantly after week 24, suggesting those who make it through the early phase generally tolerate it well long-term

If a 90% ethanol-water solution shall be mixed with clean water to achieve a freezing point of -20 o C (ethanol concentration 36.25% (0.3625) ) - the amount of added water can be calculated with volume balance - the amount of ethanol before mix is the same as after the mix: C V s = C m (V s + V w ) (2) where V s = volume of the ethanol - water solution (liter, gallon) C m = concentration in mix V m = volume of mix (liter, gallon) V w = volume of the added clean water (liter, gallon) Rearranging the equation to express the volume of water added to the mixture V w = (C - C m ) V s / C m (2b) Substituting with values V w = (0.9 - 0.3625) V s / 0.3625 = 1.48 V s - for every liter 90% ethanol-water solution 1.48 liter of clean water must be mixed in to achieve an ethanol concentration of 36.25 % and freezing point -20 o C .

Proper storage can extend usability