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Recent studies showed that aged killifish display markers of intestinal inflammation 22 and undergo expansion of large B cell clones systemically, and a decrease in naive B cell diversity in mucosal organs 24

Also, a central clock, independent of the SCN, can be entrained by food availability, temperature variations, forced activity and rest, drugs (melatonin itself), and timing (50)

It catalyzes the transfer of electrons from NADH to coenzyme Q and translocates protons across the inner mitochondrial membrane

The intestine is a critical interface for nutrient absorption, immune regulation, and microbial symbiosis (Takiishi et al., 2017)

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c