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Yamabe N, Kang KS, Park CH, Tanaka T, Yokozawa T

Neurotoxicology 55, 4857

uralensis under drought stress ( Figures 4B, C and Table 4 ), indicating that Si alone or its combination with G5 might inhibit phytoene synthesis at the substrate level by inhibiting the PSY activity resulting from the downregulation of the gene

Growing approaches targeting lysosomal proteolysis Similar to the precise targeting of proteasomal proteolysis, several technologies targeting protein degradation through lysosomal proteolysis have emerged spontaneously, including autophagy-targeting chimera (AUTAC), newly developed AUTOTAC, autophagosome-tethering compound (ATTEC), CMA-targeting motif (CTM)-directed protein degradation, and lysosome-targeting chimera (LYTAC)

The distribution of 4-HNE and similar alkenals has pharmaco-toxicological relevance: owing to the intrinsic toxicity of aldehydes, it is important to know their metabolism and fate: Alary et al