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Chvez-Iiguez, MD, Hospital Civil de Guadalajara Fray Antonio Alcalde, Servicio de Nefrologa, Guadalajara, Jalisco, Mexico

Consistent intake of Black Raspberry (BR) extract might alleviate hypercholesterolemia and hepatic inflammation induced by excessive choline with a high-fat diet via lowering the elevated level of TMA in cecal and TMAO in serum in rats, Polyphenols in BR extract reduced the level of TMA in the cecum by regulating the gut microbiota (Lim et al., 2020)

On the other hand, in case of excessive distress, cells are exposed to high levels of ROS which can cause neuroinflammation, damage to the blood-brain barrier (BBB) and impairment to astrocyte crosstalk leading to ASD (Russo et al., 2018)

Vahabzadeh Z

(2018) American Journal of Physiology | Janeiro, M., Ramrez, M., Milagro, F., et al.: Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target.(2018) Nutrients | Jaworska, K., Hering, D., Mosieniak, G