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We further used a LEGENDplex kit to quantify asthma-associated cytokine levels

These DNA-damage recognition proteins have been shown to deliver signals from DNA breaks to downstream proteins such as p53, p73 and mitogen-activated protein kinases (MAPK), which activate apoptosis and other forms of cell death [21]

Drugs such as amsacrine, etoposide, and doxorubicin target topoisomerase type II (type II), while cytotoxic alkaloids and camptothecin (CPT) are recognized as inhibitors of type I [74]

The same enzymes designed to break down dietary protein into amino acids

Although astrocytes can utilize fatty acids as an alternative energy source, prolonged reliance on lipid oxidation results in oxidative stress and mitochondrial impairment, exacerbating neurodegeneration 82