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Its efficacy has been confirmed in a phase 3 clinical trial for RR-TB, thus representing a key component of the shortened treatment regimen for DS-TB (Sarathy et al., 2019

tTregs are generated in the thymus from bone marrowderived progenitor cells, which first differentiate into CD3CD4CD8 double-negative lymphocytes, then progress to CD4CD8 double-positive thymocytes, which subsequently develop into CD4 single-positive cells