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NICE guidance (NG49) recommends fibrosis risk stratification using FIB-4 scores and Enhanced Liver Fibrosis (ELF) testing for NAFLD patients

However, these methods are limited by their aggressiveness [1]

Its well believed that innate and adaptive immunity work together during the progression of DILI, and the interaction between DCs and T cells cannot be overlooked since the damaged hepatocytes release DAMPs and toxic metabolites, which exacerbate liver injury [126, 127]