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This is a critical distinction for researchers

& Blancafort, P

It has been observed that enzymatic inactivation of cisplatin by GSTP1-1 contributes significantly to drug-resistance 77

et al., in which the authors reported the role of inducible nitric oxide synthase (iNOS) in the pathogenesis of steatohepatitis, with a protector role on increasing the expression of Heme oxygenase-1 (HO-1), similarly regulated by NRF-2 [44]

This includes members of the Firmicutes phylum (particularly within the Clostridiaceae and Lachnospiraceae families) and select opportunistic Enterobacteriaceae