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La extrapolacin de estas dosis al ser humano, utilizando los factores de conversin alomtricos estndar (factor de 6,2 para la rata), da dosis tericas del orden de 1,6 g/kg en humanos

doi: 10.1038/s41467-021-22501-9 56 CaiW.LiL.SangS.PanX.ZhongC

However, findings in a systematic review and meta-analysis of prolonged NSAID use (ranging from one to seven years) indicated NSAIDs accelerate OA progression

These studies contribute to the broader field of peptide drug design by informing the development of delivery systems and chemical modifications that enhance peptide stability in biological environments