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Semin Cell Dev Biol 147:5869

However, high-quality studies are needed to determine safety and effectiveness, and it cannot be recommended as a replacement therapy for insulin or hypoglycemic drugs

This emerging integrative and functional nutrition model of psychiatric medicine is rooted in systems biology that seeks to unravel the genetic, epigenetic, and metabolic mechanisms related to inflammation, the microbiota-gut-brain axis, oxidative stress/mitochondrial dysfunction, and nutrient deficits.3 The biological basis of mental illness lends itself to nutrition and lifestyle measures that enhance neuroplasticity and brain resiliency.4 RDs can assess these physiological areas to identify imbalances that can be modified through diet and supplements tailored to the individual and design a personalized intervention and treatment plan

Given its involvement in regulating mitochondrial glutathione (GSH) levels, both SLC25A39 and mitochondrial GSH emerge as potential therapeutic targets for CRC