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Cases of localized skin and soft tissue necrosis occurring as sequelae of penile hematoma, some requiring surgical intervention, have been reported post-marketing Hypersensitivity Reactions, Including Anaphylaxis: In the double-blind, placebo-controlled portions of the clinical trials in Peyronies disease, a greater proportion of XIAFLEX-treated patients (4%) compared to placebo-treated patients (1%) had localized pruritus after up to 4 treatment cycles (involving up to 8 XIAFLEX injection procedures)

TGF-1 levels are significantly elevated in the synovial fluid and tissues of RA patients, where it contributes to disease progression by promoting fibroblast proliferation, synovial hypertrophy, and extracellular matrix degradation (Bira et al

Because thyroid hormones affect so many parts of the body, hyperthyroidism can have serious consequences

In our study, we examined the heartbeat of 4-dpf F1 transgenic fish larvae carrying either LMNA (WT) or LMNA mutants

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