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Blood 111:31453154

When the gut lining is inflamed and damaged, the gut lining is more porous than it should be

Front Cardiovasc Med (2019) 6:51

Rothstein 1995

Addition of a methyl group (-CH3) to the 3 position changes morphine to codeine, masks the OH group and confers greater fat-solubility to the molecule allowing it to be more preferentially absorbed