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Women with high cytoplasmic levels of IGF-1R in epithelial cells found in benign terminal duct lobular units (TDLUs) biopsies, have up to 15 times increased BrCa incidence [72]

Unfortunately, this study did not clearly state the manufacture of the topical cream and its concentration

The 4E-BPs are small (~1520 kDa) proteins that interact with eukaryotic translation initiation factor 4E (eIF4E) inhibiting translation initiation, this being a very important regulation point in protein translation