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1 Introduction Bullfrog belongs to Amphibia, Frog family, native to North America, is an aquaculture animal with high efficiency in producing high quality protein, which was introduced to our country from Cuba in the 1960s

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HHQs are most commonly synthesized through multicomponent reactions, with Hantzsch-type condensations remaining the dominant synthetic route due to their operational simplicity, and ability to rapidly generate molecular diversity ( More recently, significant efforts have focused on improving the efficiency, sustainability, and scope of HHQ synthesis

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PMC 2409172

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& Iyengar, N

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485 Recently, several studies have shown improvements in histological markers of NASH and fibrosis with obeticholic acid treatment

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