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VDR activation upregulates the production of antimicrobial peptides (e.g., cathelicidin and defensins) and enhances the expression of tight junction proteins, including occludin and claudins (Hamza et al., 2023)

Inhibition of cysteine in retinal pigment epithelial cells induced GSH depletion, ultimately resulting in ferroptosis, autophagy, and premature senescence 39