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Fibroblasts in MCTD-affected tissues become dysregulated, resulting in excessive extracellular matrix (ECM) deposition and fibrosis

500% and 400%, respectively) increase in the beam balance score relative to the control groups

This rigidity enforces a defined molecular conformation that aligns DSF favorably within the binding pockets of different proteins, optimizing hydrophobic and van der Waals interactions

In another HDM- asthmatic mouse model, pterostilbene was administered intraperitonially at 10, 20, or 40 mg/kg/day for 4 days as a prophylactic measure before inducing asthma [207]

Conserved motifs were identified among the proteins, particularly in critical structural-functional regions (Fig