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These compounds aim to reduce inflammation, restore tissue homeostasis, and promote tissue regeneration by modulating the environment surrounding senescent cells.130 Unlike senolytics, which focus on cell death, senomorphics maintain the senescent cells presence but modify its behavior, particularly the pro-inflammatory and tissue-damaging components of the SASP.129 By reducing the detrimental effects of senescent cells, such as the SASP, senomorphics hold promise for treating a range of diseases, including cancer, neurodegenerative disorders, cardiovascular diseases, and metabolic syndromes.26 At the molecular level, senomorphics exert their effects primarily by modulating the signaling pathways that govern SASP production without inducing apoptosis in senescent cells

More comprehensive studies are needed to fully understand its effects and potential applications

Mitochondrial Lon-induced mtDNA leakage contributes to PD-L1-mediated immunoescape via STING-IFN signaling and extracellular vesicles

In other words, homocysteine is likely a marker of a healthy diet and lifestyle, and not a target to address in its own right

Its potential benefits for hair health may include supporting hair strength and elasticity