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34 In preclinical studies, this phenomenon is independent of the effect on osmotic pressure, and albumin is more effective than semisynthetic colloids at preserving and restoring the endothelial glycocalyx, reducing vascular permeability, and reducing platelet and leucocyte adhesion.35, 36 However the ability for albumin to protect glycocalyx integrity in clinical studies has yet to be examined

Spectra scans were acquired in Q-Exactive mass spectrometry instrument (Thermo Scientific, USA), coupled to a nano UHPLC system via a nanoelectrospray ion source