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doi: 10.1016/j.bcp.2005.09.021, 117

C-terminal splice variants of the mouse mu-opioid receptor differ in morphine-induced internalization and receptor resensitization

Mitochondrial dysfunction Disruption of mitochondrial defense mechanisms is mediated by the Parkin and PTEN-induced kinase 1 (PINK1) genes which are critical for mitophagy, a process that removes dysfunctional mitochondria from cells